De nieuwe medisch directeur, Max Goodwin, begint aan zijn baan in het oudste ziekenhuis van Amerika. Hij wil de bureaucratie bestrijden en uitzonderlijke zorg bieden.
Gastrollen:
Yvette Ganier(E.D. Nurse Linda Weber), Olivia Khoshatefeh(E.D. Resident Yasmin Turan), Lisa O'Hare(Georgia Goodwin), Megan Byrne(Gladys), Michael Basile(Paramedic Moreland), Christine Chang(Dr. Agnes Kao), Emma Ramos(E.D. Resident Mariana), Stacey Raymond(Paramedic Kerry Whitaker), Zabryna Guevara(Dora), Lizzy DeClement(Jemma), Greta Quispe(Nurse Sabrina), SHukura(Raina), Troy Iwata(ED Intern Garo Rose), Rose Bianco(Patricia), Jason Kisare(Alain), Gary Perez(Carlos Martin), Alanna Blair(Teacher), Eric Martin Brown(TV Anchor Dan), Paula Cajiao(Patricias Daughter #2), Antoinette Cirillo(ISO Nurse), Donnetta Lavinia Grays(Sophia), Gregory Jones(NSA Agent Bratton), Vanessa Kai(Dr. Suzanne Izuka), Michael Medeiros(Russian Ambassador), Ammie Montas(Patricias Daughter #1), Jay Santiago(Patricias Father), Liba Vaynberg(I.C.U. Nurse April Kosloff), Anthony Ruiz(Miguel Vicario), Lisa Wing Huntzinger(Team Member #2), Elisabeth Garcia(Team Member #1), Natalie Carvalho(Bianca), Katherine Costanzo(ER Nurse #1), Yvette Garnier(ED Nurse Linda Weber), Irma Estella La Guerre(Patricias Mother), Raúl Torres(Mexican Ambassador)
