In de nasleep van Halsteads flatbrand werken Marcel, Choi en Archer samen om de overlevenden te redden; De nieuwe collega van Charles en Med, Cuevas, helpt een paranoïde patiënt; Scott neemt een levensveranderende beslissing.
Gastrollen:
Yaya DaCosta(April Sexton), Brian Tee(Dr. Ethan Choi), Jeremy Shouldis(Dr. Marty Peterson), Lorena Diaz(Nurse Doris), Brennan Brown(Dr. Sam Abrams), Marc Grapey(Peter Kalmick), Michael Vaughn Shaw(X-Ray Tech Mike), Kara Killmer(Sylvie Brett), Cesar Jaime(Paramedic Cesar), David Eigenberg(Christopher Herrmann), Marina Squerciati(Kim Burgess), Tim Hopper(Captain Tom Van Meter), Steven Weber(Dr. Dean Archer), Guy Lockard(Dr. Dylan Scott), Sarah Rafferty(Dr. Pamela Blake), Curtiss Cook(Lt. Reginald Scott), Riley Voelkel(Jo), Wayne T. Carr(Grant Young), Karin Anglin(Patty Sullivan), Bryan Coffee(Dr. Edward Horowitz), Madison Dirks(Eric Sullivan), Lilah Richcreek(Dr. Nellie Cuevas), Lynnette Li(Nurse Nancy), Angela Wong Carbone(Jessa Rinaldi), Asjha Cooper(Dr. Vanessa Taylor), Karmann Bajuyo(Dr. David Jones), John Henry Ward(David Sullivan), Mike Jimerson(Bodgan Kostovic), Mehmet Can Aksoy(Goran Kostovic), Khaki Pixley(Fitzgerald)